Although Calamary's health and attack damage aren't too high, she can be quite an annoying enemy due to her ability: She is long-ranged and has the ability to lower attack power of cats to 10% (for example, a unit that would normally deal 100,000, would only deal 10,000), so be wary when fighting her! However, if you have units that resist weaken (like Akira, Pai-Pai, Lesser Demon Cat, Mad Doctor Klay or King Gamereon, Divine Kuu), she is easy prey.
Due to Calamary's long range, Aphrodite is recommended as her range is 600 and she inflicts massive damage against Aliens, so she will land mighty, non-weakened blows. Li'l Nyandam is a non-Uber alternative.
If Calamary is being defended by peons, Crazed Gross Cat will be effective, as the waves resulting from an attack will reach her and deal moderate damage. Akira can be super useful against her as he is effective against Aliens in all forms and cannot be Weakened.
Ship crash-landed near the famous Tsukiji fish market. She introduced a new translucent style sense that's now tres chic at the harbor. Greatly weakens opponent's attack.