Lowkey is very similar to Black Okame, with high health, rapid attacks, one knockback and long range, but extremely slow movement speed. Like most other Relic enemies, it has a 100% chance of inflicting curse, which combined with its range of 500 can be deadly under the right circumstances.
Similar to Othom and other long ranged Relic enemies, Lowkey's attack power is still relatively low, and combined with his extremely sluggish movement speed, it will never be able to push far on its own. Within 2★, Lowkey should be taken with considerably more attention, as now he will have 1,666,666 health, 9,000 damage per hit, and a slightly more increased number of 6,585 damage per second. Due to the nature of Lowkey, this makes his most dangerous traits more dangerous.
Just as with most Relic enemies, any short-ranged units that rely on abilities against traits should not be used due to curse mechanics, and those that should be used should either be long-ranged units (Cyberpunk Cat, Awakened Mina, etc.) or tanky high DPS units like Manic Island Cat and JamieraCatvariants that can survive Lowkey's fast, long-ranged attacks; or Idi:N even should you have it. Keep in mind the 500 range means that many non-Uber units wont be able to outrange it, and for those that can may still need a stepping stone to hit with piercing range.