This enemy has many knockbacks, short range and an Area Attack with a 100% chance to knockback cats and create a Lv.3 Shockwave.
Due to Ms. Madonna's low damage output, the player can use tanky units like Island Cat or Jamiera Cat, or Wave Immune cats like Miyamoku Musashi. Note that due to being knocked back with the first attack, Octopus Cat will not block the wave attack if he's in Ms. Madonna's range (130<200). This enemy can be dealt with very easily when she's alone, but when supported by heavy hitters such as Teacher Bun Bun or Zang Roo, she can become quite the nuisance.
You can also use cats that are immune to knockback to prevent the enemies front line from moving forwards, this is especially important in later stages when there are powerful backliners that could advance. It is best to defeat her as fast as possible as she can become an annoying support for the enemies.