Zamelle has much higher attack power and health than her normal counterpart, but with slower movement speed. She also has the base destroyer ability, and is only knocked back when killed. The biggest thing that stands out about this enemy is her ability to revive herself an infinite amount of times after dying, with a longer-than-usual attack cooldown.
Use a unit with the Zombie Killer ability such as Vaulter Cat or Hyper Mr. against this enemy when it is near death, using damage calculations. This way, it will die permanently instead of reviving. Sifu Cat is especially effective for this as he can tank many hits from the Zamelle while chipping it down. If using him, avoid spawning non-Zombie-Killers, as they may get the last hit. Despite lacking the Zombie Killer ability, Island Cat, together with its Crazed/Manic variant, are great units as they can attack Zamelle several times before death, dealing incredibly high damage in just a few cycles. Similar to Camelle, this enemy can be easily dispatched using long-ranged units, but it won't do much good if not zombie killed. If you are unable to permanently kill this enemy, use fast units like Maglev Cat, Manic Lion Cat, or Awakened Bahamut Cat to get behind it while it is temporarily dead to attack the base, although this will most likely lead to your death in it's debut stage.